Introducing the
A diverse class of therapeutic agents uniquely suited to target toxic intrinsically disordered proteins (IDPs) involved in the propagation of multiple diseases such as Type 2 Diabetes, neurodegeneration and cancers.
How It Works
IDPs are unstructured proteins, lacking the stable binding pockets needed for small molecule therapeutics, making them traditionally undruggable targets. Examples are: Islet amyloid polypeptide (IAPP), in the case of Type 2 Diabetes; alpha-synuclein, in the case of Parkinson’s Disease; and Myc, in the case of several tumors. During disease progression, IDPs miss-assemble and become toxic to cells.
Pangolin Therapeutics uses a combination of molecular modeling, biophysics, synthetic organic chemistry and other tools of drug discovery to produce Pangomers selectively designed to interfere with a specific toxic IDP and halt disease progression.
Pangomers are Amazing Molecules
- Features of peptide mimetics and small synthetic organics
- Chemically tunable folding dynamics
- Engage targets selectively, remodeling or dissociating them
- Water Soluble
- Membrane Penetrating
- Stable
- Safe
Pangolin Therapeutics’ Market Potential
IDPs comprise over one-third of the human proteome. Pangolin has the potential to build a rich pipeline of products in high medical need areas.
While today the focus is on Type 2 Diabetes, where there is an ever growing market and need for agents with new mechanisms of action, programs in neurodegeneration are underway.
Pangolin is about:
- First-in-class drugs with the potential for disease modification or cure
- Multiple assets ripe for collaboration and licensing
$9,500,000
in NIH, state and private funding has been invested in the Pangomer Platform.
Meet the Leadership
Pangolin Therapeutics is led by an experienced team that understands the business of science.
Enrique Alvarez Sotomayor, DMV, MA
Co-Founder and CEO
- 25-year Biotech & Pharma Pre-Clinical Expert
Andrew Miranker, PhD
Co-Founder, Scientific Advisory Board Chair
- 25-year Computational Design, Biophysics & Biochemistry Leader
- Professor, Molecular Biophysics & Biochemistry, Yale University
Pangolin Therapeutics is supported by an accomplished Scientific Advisory Board led by Dr. Miranker:
Peter Farina, PhD
- Expertise: Organic chemistry, pharmaceutical R&D; 28 years of experience
- Senior Vice President of Development, Boehringer Ingelheim NA
Carolyn Fredericks, MD
- Expertise: Imaging, neurodegenerative diseases
- Assistant Professor, Department Neurology, clinician, Yale School of Medicine
Andrew Hamilton, PhD, FRS
- Expertise: Protein mimetic chemistry
- Professor of Chemistry and President, New York University
Richard Kibbey, MD/PhD
- Expertise: Islet biology, Type 2 Diabetes, clinician
- Associate Professor of Internal Medicine, Endocrinology & Cellular & Molecular Physiology, Yale University
Liz Rhoades, PhD
- Expertise: Biophysical chemistry of disordered proteins; 16+ years in Parkinson’s and TBI
- Professor of Chemistry, University of Pennsylvania